Phase12Compare: Simulates SPSO and Efftox Phase 12 Trials with Correlated Outcomes

Simulating and conducting four phase 12 clinical trials with correlated binary bivariate outcomes described. Uses the 'Efftox' (efficacy and toxicity tradeoff, <>) and SPSO (Semi-Parametric Stochastic Ordering) models with Utility and Desirability based objective functions for dose finding.

Version: 1.5
Imports: Rcpp (≥ 0.12.18), mvtnorm
LinkingTo: Rcpp, RcppArmadillo
Published: 2020-07-31
DOI: 10.32614/CRAN.package.Phase12Compare
Author: Andrew G Chapple
Maintainer: Andrew G Chapple <achapp at>
License: GPL-2
NeedsCompilation: yes
CRAN checks: Phase12Compare results


Reference manual: Phase12Compare.pdf


Package source: Phase12Compare_1.5.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): Phase12Compare_1.5.tgz, r-oldrel (arm64): Phase12Compare_1.5.tgz, r-release (x86_64): Phase12Compare_1.5.tgz, r-oldrel (x86_64): Phase12Compare_1.5.tgz
Old sources: Phase12Compare archive


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